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Mordhwaj PariharProfessor & Chair Departments of Zoology & Biotechnology; Dean Life Science Faculty at Vikram University Ujjain
One of the silent features in Alzheimer's disease is the retraction of synapses that will affect mostly recalling short term memories. However, there also results in activation of some new connections that increase insanity. Is there any treatment to curb such features in these patients that prevent faulty neuronal connections?...
Hello, at last, some thinking about thinking about what are the root/first causes of the symptoms we label Alzheimer's Disease. Their conclusion, it's complicated, really complicated. It's somehow age related, most of the time. Did I mention it's complicated? Of course the author of the article is also the founder of a drug company currently developing drugs based on his research, and he now seems to be using his lofty position at Stanford to mention from time to time his research. Just a coincidence I'm sure. It's complicated.
Hello, most everyone know de-nial is both the name of a river in Egypt and a condition of belief many older folks hold on tight too, especially when the symptoms of dementia are apparent. This strategy to avoid dealing with the feelings growing out of the stigmas, half-truth, and complete misunderstandings about dementia and its many symptoms does not serve the needs of anyone.
Hello, yet more good news for nude mice. Yet, more false hope for human beings living with the symptoms of dementia. Mice, nude or not, do not "get" Alzheimer’s disease. They "get" a poor memory. As experts are fond of reminding us, Alzheimer’s disease is not just about a bad memory - that's just true for mice. We are not even sure if mice can't remember, in the same exact sense as human beings recall/reconstruct previous experience and base decisions upon those consistent recollections. We just say, they have "poor memories", mice that is.
Hello, I'm not implying that I have a lot of rats reading my Facebook page by featuring this possible breakthrough news, but I am intrigued by how familiar the strained leap is from this finding to hope and support for those living with the symptoms of dementia. More news I found:
"The researchers found that the neurons in the 3D brain-like tissues had higher expression of genes involved in neuron growth and function. In addition, the neurons grown in the 3D brain-like tissue maintained stable metabolic activity for up to five weeks, while the health of neurons grown in the gel-only environment began to deteriorate within 24 hours. In regard to function, neurons in the 3D brain-like tissue exhibited electrical activity and responsiveness that mimic signals seen in the intact brain, including a typical electrophysiological response pattern to a neurotoxin.
Researches recorded changes which proved similar to what was originally observed…
Because the 3D brain-like tissue displays physical properties similar to rodent brain tissue, the researchers sought to determine whether they could use it to study traumatic brain injury. To simulate a traumatic brain injury, a weight was dropped onto the brain-like tissue from varying heights. The researchers then recorded changes in the neurons’ electrical and chemical activity, which proved similar to what is ordinarily observed in animal studies of traumatic brain injury."
It's a good thing this society doesn't like rats, in fact fears them. You don't see many folks breaking into labs to free the rats. These researchers apparently drop weights inside the heads of live rats to see what damage does to their newly created rat brain cells.
Oh well, onward through the fog, much of which we create and ignore ourselves.